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Colombian artist Fernando Botero is putting his longtime Manhattan home and art studio on the market for $6 million, according to his daughter Lina Botero.

Mr. Botero, who hails from Medellín, is known for his sculptures depicting oversize human and animal characters, which have been displayed prominently in locations such as New York’s Time Warner Center and on the Champs-Élysées in Paris. One of his pieces, “El Gato,” an oversize bronze of a cat, used to sit outside the building, at 900 Park Avenue on the corner of East…