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A trio of world-class runners will attempt to complete a marathon in under two hours early Saturday, the culmination of an audacious Nike Inc. marketing stunt that would require shaving nearly three minutes off the current world record.

Nike has been planning this moment for years. The company developed new, technically sophisticated footwear for the project. And it curated a roster of elite runners game for the task. It selected an ideal running surface and climate—a Formula One race track in Monza, Italy—for the race….